Detalhe da pesquisa
1.
CYP7A1 Gene Induction via SHP-Dependent or Independent Mechanisms can Increase the Risk of Drug-Induced Liver Injury Independently or in Synergy with BSEP Inhibition.
Drug Metab Dispos
; 52(5): 432-441, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38485279
2.
Assessing Pleiotropic Effects of a Mixed-Mode Perpetrator Drug, Rifampicin, by Multiple Endogenous Biomarkers in Dogs.
Drug Metab Dispos
; 52(3): 236-241, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123963
3.
Survey of pharmaceutical industry's best practices around in vitro transporter assessment and Implications for Drug Development: Considerations from the IQ Transporter Working Group.
Drug Metab Dispos
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38697852
4.
The Role of Coproporphyrins As Endogenous Biomarkers for Organic Anion Transporting Polypeptide 1B Inhibition-Progress from 2016 to 2023.
Drug Metab Dispos
; 51(8): 950-961, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37407093
5.
Characterization of Elimination Pathways and the Feasibility of Endogenous Metabolites as Biomarkers of Organic Anion Transporter 1/3 Inhibition in Cynomolgus Monkeys.
Drug Metab Dispos
; 51(7): 844-850, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37059471
6.
Interpretation of Protein-Mediated Uptake of Statins by Hepatocytes Is Confounded by the Residual Statin-Protein Complex.
Drug Metab Dispos
; 51(10): 1381-1390, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37429727
7.
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection.
Xenobiotica
; 52(9-11): 973-985, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36546430
8.
Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition.
Drug Metab Dispos
; 49(12): 1063-1069, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34599018
9.
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Drug Metab Dispos
; 49(2): 159-168, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33051248
10.
Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides: Where Is the Evidence for Its Relevance in Drug-Drug Interactions?
Drug Metab Dispos
; 48(3): 205-216, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879282
11.
In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.
Drug Metab Dispos
; 48(12): 1283-1292, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33037043
12.
Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.
Drug Metab Dispos
; 48(8): 724-734, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32482623
13.
Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo.
Drug Metab Dispos
; 47(12): 1433-1442, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31582395
14.
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.
Drug Metab Dispos
; 47(4): 350-357, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622164
15.
Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.
Drug Metab Dispos
; 47(10): 1122-1135, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31266753
16.
Special Section on Drug Metabolism and Precision Medicine-Editorial.
Drug Metab Dispos
; 51(3): 348-349, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36849441
17.
Special Section on Xenobiotic Receptors-Editorial.
Drug Metab Dispos
; 51(2): 205-206, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36702490
18.
Special Section on Perspectives on Drug Metabolism and Disposition, Part I-Editorial.
Drug Metab Dispos
; 51(6): 645-646, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37169510
19.
Special Section on Mechanism-Based Predictive Methods in Drug Discovery and Development-Editorial.
Drug Metab Dispos
; 51(9): 1064-1066, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37586888
20.
Drug Transporters in Xenobiotic Disposition and Pharmacokinetic Prediction.
Drug Metab Dispos
; 46(5): 561-566, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29636376